Job Information
Astellas Pharma Senior Research Associate, Bioanalytics in South San Francisco, California
Sr. Research Associate, Bioanalytics
Do you want to be part of an inclusive team that works to develop innovative therapies for patients? Every day, we are driven to develop and deliver innovative and effective new medicines to patients and physicians. If you want to be part of this exciting work, you belong at Astellas!
Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .
About Astellas Gene Therapies
Astellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly-created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco and Sanford, North Carolina. For more information, please visit our website: www.astellasgenetherapies.com.
The Role
The primary purpose of the Senior Research Associate in Bioanalytics is to analyze tissue samples taken from our nonclinical research studies dosed with gene therapy candidates. The Senior Research Associate will process tissues for critical endpoints, run analysis on the appropriate instrument, and analyze data outcomes. In addition, the Senior Research Associate will QC data, optimize protocols, and assist in new assay development.
Responsibilities
Extract protein, DNA and/or RNA from necropsied animal tissue
Run ddPCR, qPCR, ELISA, Western Blot etc analysis on tissue extracts
Cell culture, Neutralizing antibody assays and total antibody assays
Sample analysis assay optimization
SOP writing
Data recording and analysis
QC analysis
This position directly impacts preclinical outcomes including proof of concept, ED50, MED, clinical hold response and IND enabling studies
Qualifications
Bachelor’s degree in Molecular Biology, Biology, Life Sciences, or a related discipline with 5+ years of experience or a Master’s Degree with 3+ years of industry experience in molecular and cell biology techniques.
Ability to perform tissue extraction manually and on automated platforms
Proficient in qPCR & ddPCR
Proficient in RNA handling/storage and cDNA synthesis
Experienced using sterile technique and molecular assay handling
Proficient in QuantStudio Design and Analysis Software, QuantaSoft Software, and ImageJ
Experienced in quality control assessment
Experience in assay development/optimization
Preferred
Experience with Quality Assurance compliance and GLP-like procedures
Experience with SOP writing
Experience with Electronic Notebook Record Keeping
Working Conditions
This is a hands-on laboratory-based position that requires onsite work
Salary Range : $114,800 - $153,000 (NOTE: Final salary could be more or less, based on experience)
Benefits:
Medical, Dental and Vision Insurance
Generous Paid Time Off options, including Vacation, Sick time, plus national holidays including Heritage Days, and Summer and Winter Breaks
401(k) match and annual company contribution
Company paid life insurance
Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions
Long Term Incentive Plan for eligible positions
Referral bonus program
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability.
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Category GT - Discovery Bioscience
Astellas is committed to equality of opportunity in all aspects of employment.
EOE including Disability/Protected Veterans
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